?PMS anyone??
By schun, Section Biology Posted on Fri Apr 30th, 2010 at 03:34:45 PM PST
Premenstrual Syndrome is collection of symptoms or sensations women experience as a result of high hormone levels (Estrogen and Progesterone). Symptoms include anxiety, irritability and mood swings. If estrogen predominates, anxiety occurs. If there's more progesterone, depression may be a complaint.

Estrogen and progesterone act by binding to its appropriate receptor. However, the variance of PMS varies between women from symptom free to extreme sensitivity. I would like to propose a study to see if these variance in women are due to genetic variant at the appropriate hormonal receptor level. I would need a large number of healthy female subjects, their hormonal level will be checked during ovulation, and will be grade their PMS on a scale 1-5 (1= symptom free 5= extremely emotional) Then, we would look for genetic variance between each level (more likely compare those in 1 and 5)

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