epigenetic approach, such as DNA methylation or histone modification. The example

include MLH1 methylaiton in colorectal cancer. This idea is to find genes inactivated in the

epigenome through populations, The approach is the same as normal Genome wide

association study (GWAS), the difference is the target.

Detail:

1. Get patient sample and normal sample from some tissue, like colon.
2. Get DNAs from the sample and treat with bisulfite.
3. Bisulfite chip (if there is*)
4. analysis of the data from patient and normal.

CpG island Chip is not accurate enough to locate genes. and it is doable as what they need

to do is just bisulfite convert the sequence they usually attach to the chip)